stem cell treatment for knees osteoarthritis

High dose cohort, (at medial femoral and tibial condyles): Radiographic: articular cartilage volume) WOMAC = Western Ontario and McMaster Universities Osteoarthritis Index MOAKS = MRI Osteoarthritis Knee Score AOFAS = American Orthopedic Foot and Ankle Score VAS = Visual Analogue Scale ROM = Range of Motion HHS = Harris Hip Score FAOS = Foot and Ankle Outcome Score ICOAP = intermittent and constant osteoarthritis pain WORMS = Whole-Organ Magnetic Resonance Imaging Score KSS = Knee Society Clinical Rating System KOOS = Knee Injury and Osteoarthritis Outcome Score IKDC = International Knee Documentation Committee MOCART = Magnetic Resonance Observation of Cartilage Repair Tissue ICRS = International Cartilage Repair Society CMC = carpometacarpal DASH = Disability of the Arm, Shoulder, and Hand scoring system hUCB-MSCs = human umbilical cord blood-derived mesenchymal stem cells SAS = Short Arthritis Assessment Scale OARSI/OMERACT = Osteoarthritis Research Society International/Outcome Measures in Rheumatology response defined as 20% improvement of VAS and WOMAC from baseline HAQ = Health Assessment Questionnaire OAOS = Osteoarthritis Outcome Score G-CSF = granulocyte colony stimulating factor SVF = stromal vascular fraction PRP = platelet-rich plasma GFA = Growth Factor Addition NPS = Numeric Pain Scale GUG = Get-u and Go test SCT = Stair Climbing Test RPE = Rate of Perceived Exertion dGEMRIC = delayed gadolinium-enhanced magnetic resonance imaging of cartilage ECM = extracellular matrix JKOM = Japanese Knee Osteoarthritis Measure LEFS = Lower Extremity Functional Scale. Data extraction and assessment of study quality Exclusion criteria were articles that did not use MSCs to directly treat OA patients, that were reviews, conference submissions/abstracts only or letters to the editor, that studied stem cells in vitro, that studied isolated, focal chondral defects not associated with OA, and that presented their research in a language other than English. Articles from any country were acceptable but limited to those published in the English language. These measures included safety analyzed by the nature of adverse events, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Visual Analogue Scale (VAS) for pain, radiographic MRI or X-ray scores, as well as several others. Outcome measures varied amongst articles. Inclusion criteria was any clinical study that used stem cells to treat osteoarthritis in humans. After identifying the relevant studies through abstract information, studies were included after full-text evaluation.

Third and fourth reviewers (TE and EC) resolved any discrepancies for inclusion. Two reviewers (DJ and AA) independently evaluated studies.

Stem cell treatment for knees osteoarthritis